A method is disclosed for determining whether a human having Crohns disease is likely to respond to a therapy targeting a TNFSF member or a cytokine by measuring the level of certain mRNAs in response to a stimulus. A method of evaluating the effectiveness of a Crohns disease therapy in a human is also disclosed. Furthermore, a method of screening compounds for use in the treatment of Crohns disease is disclosed. A method of monitoring the disease state over time in Crohns disease patients is also disclosed.