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MODULATION DE LA SYNTHESE ET DE LA DEGRADATION DE L'HYALURONANE DANS LE CADRE DU TRAITEMENT DE MALADIES
专利权人:
MEDITECH RESEARCH LIMITED
发明人:
BROWN, TRACEY JEAN,BROWNLEE, GARY RUSSELL
申请号:
CA2541438
公开号:
CA2541438C
申请日:
2004.10.11
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
Modulation of Hyaluronan (HA) synthesis and degradation is disclosed bycompounds and compositions that are capable of reducing the level ofhyaluronan synthase (HAS) or hyaluronidase (HYAL) or the function or activityof HAS or HYAL. The compounds and compositions can also inhibit the expressionof genetic material encoding these enzymes. The compounds and compositionscomprise nucleic acid molecules and interactive molecules such as antibodies,small molecule inhibitors and substrate analogs of HAS and HYAL. The compoundsand compositions are useful in the prophylaxis and/or treatment ofinflammatory disorders including hyperproliferative conditions, such as butnot limited to, cancer and psoriasis.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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