DYMEK, BARBARA,ZAGOZDA, MARCIN,WIECZOREK, MACIEJ,DUBIEL, KRZYSZTOF,STANCZAK, ALEKSANDRA,ZDZALIK, DARIA,GUNERKA, PAWEL,SEKULAR, MARIOLA,DZIACHAN, MACIEJ
申请号：
CA2978828
公开号：
CA2978828A1
申请日:
2016.03.30
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
A compound of the general formula (I) wherein Y represents -CH2- or >；C=0； R1is selected from the group consistingof A1, A2 and A3； R2 represents dioxothiomorpholino moiety B1, piperazinylmoiety B2, azetidinyl moiety B3, or piperidinylmoiety B4； R3 is selected from the group consisting of H, halogen, and C1-C4alkyl； R4 is selected from the group consisting of C1-C4alkyl, C3-C4- cycloalkyl, C1-C4 alkyl substituted with C1-C4 alkoxy, and CHF2, and their pharmaceutically acceptable salts.Pharmaceutical compositions comprising said compounds and their use in thetreatment of diseases of immune system, inflammatorydiseases and cancer.
