An image registration device includes: an image acquisition unit that acquires plural images captured in time series； a pixel value change acquisition unit that acquires a pixel value change at the same position of each of the images for plural positions of each image； a clustering unit that clusters the pixel value changes acquired for plural positions of each image into plural classes； a region division unit that divides each of the images into plural regions based on information of the class of each pixel of each image and a pixel value of each pixel of each image； and a registration processing unit that performs registration processing on each image based on information of plural regions of each image.
