The present invention relates to an improved process for the preparation of Clomipramine salts, particularly Clomipramine hydrochloride of Formula I and Clomipramine sulfate of Formula II. The process for the preparation of Clomipramine hydrochloride of Formula I comprises of reacting 3-chloroiminodibenzyl with N,N-dimethylaminopropyl chloride in an aromatic hydrocarbon in presence of an alkali metal hydroxide； filtering the reaction mixture, cooling, diluting with water and adding aqueous sulfuric acid to obtain crude Clomipramine sulfate； recrystallizing the crude Clomipramine sulfate using acetone-water mixture to obtain Clomipramine sulfate of Formula II having HPLC purity of more than 99.5%； suspending Clomipramine sulfate of Formula II in water, adding an aqueous alkali metal hydroxide solution and an aliphatic hydrocarbon, stirring and separating an aqueous layer and an organic layer； charcoalizing the organic layer, cooling and adjusting pH by addition of alcoholic hydrochloride to yield Clomipramine hydrochloride of Formula I having HPLC purity of more than 99.7%.
