For treating the subject of inflammatory disease, the inhibition Hom-1 of the nucleic acid molecules expression including giving subject with this need. Specifically, which is RNAi reagents or antisense morpholino oligonucleotides. Method is also disclosed to select the treatment subject for inflammatory disease, or the subject for being used to treat inflammatory conditions the effect of monitoring, the Inflamed tissue Hom-1 of the expression including detection is obtained from the sample of subject.