IYER, SRIRAM,KIPSHIDZE, NICHOLAS,NIKOLAYCHIK, VICTOR,ROUBIN, GARY
申请号：
PL04755564
公开号：
PL1638624T3
申请日:
2004.06.18
申请国别(地区):
PL
年份:
2014
代理人:
摘要：
Devices and methods for reducing, eliminating, preventing, suppressing, or treating tissue responses to hemostatic devices e.g., biological sealants or vascular procedures are disclosed. The invention employs a combination of resorbable, biocompatible matrix materials and a variety of therapeutic agents, such as antiproliferatives or antibiotics, applied to a vascular puncture or incision to achieve hemostasis following diagnostic or interventional vascular catheterizations and to treat neointimal hyperplasia and stenosis. A matrix of a material such as collagen provides a reservoir of a therapeutic agent such as rapamycin (sirolimus) and its derivatives and analogs for delivery at a tissue site at risk for vasculoproliferation, infection, inflammation, fibrosis or other tissue responses.
