LIU YONG-JUN,VOO KUI SHIN,BOVER LAURA,TSURUSHITA NAOYA,TSO J YUN,KUMAR SHANKAR
申请号：
IN1363/DELNP/2014
公开号：
IN2014DN01363A
申请日:
2014.02.24
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Human antibodies preferably recombinant human antibodies both humanized and chimeric which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full length antibody or an antigen binding portion thereof. The antibodies or antibody portions are useful for modulating receptor activity e.g. in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids vectors and host cells for expressing the recombinant human antibodies are provided and methods of synthesizing the recombinant human antibodies are also provided.
