PROBLEM TO BE SOLVED: To provide a nonaqueous composition containing adipose particles holding a medicament, which nonaqueous composition allows a medicament-containing adipose emulsion usable as an injection, an eye drop, a nasal drop, an inhalation or the like to be prepared by being mixed with an aqueous medium in use, though having a high content of fats and oils to allow adipose particles to carry more amounts of a medicament than nonaqueous compositions containing adipose particles holding a medicament described in a patent document 1 (Japanese Unexamined Patent Publication No. 2010-270023).SOLUTION: The nonaqueous composition containing the adipose particles holding a medicament according to the present invention is a medicament-containing adipose emulsion containing a slightly water-soluble medicament, an oil-and-fat, an emulsifier, and water at least as the constituent components. The nonaqueous composition is obtained by allowing a saccharide and/or an amino acid as a water-soluble carrier to carry the adipose particles holding the medicament contained in the medicament-containing adipose emulsion regulated so that the content of the oil-and-fat is 2-120 mg/mL (2 mg/mL exclusive), the weight ratio (medicament/oil-and-fat) of the medicament to the oil-and-fat is 0.0001-50 (with the proviso that the total content of the medicament and the oil-and-fat is 125 mg/mL at the maximum), the content of the emulsifier is 30-200 mg/mL (30 mg/mL exclusive), and the turbidity is 0.5 or less, in a state in which an aqueous phase is substantially removed.SELECTED DRAWING: NoneCOPYRIGHT: (C)2019,JPO&INPIT【課題】 特許文献1(特開2010-270023号公報)に記載の薬物を保持した脂肪粒子を含む非水系組成物よりも、脂肪粒子が多くの量の薬物を担持することができるように油脂の含量が多いにもかかわらず、注射剤や点眼剤や点鼻剤や吸入剤などとして用いることができる薬物含有脂肪乳剤を、用時に水系媒体と混合することで調製することができる、薬物を保持した脂肪粒子を含む非水系組成物およびその製造方法を提供すること。【解決手段】 本発明の薬物を保持した脂肪粒子を含む非水系組成物は、水難溶性薬物、油脂、乳化剤、水を少なくとも構成成分とする薬物含有脂肪乳剤であって、油脂の含量が2~120mg/mL(但し2mg/mLを除く)、油脂に対する薬物の重量比率(薬物/油脂)が0.0001~50(但し薬物と油脂の合計含量は最大で125mg/mL)、乳化剤の含量が30~20
