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IMPLANTS OCULAIRES AVEC REVÊTEMENT
专利权人:
RE-VANA THERAPEUTICS LTD
发明人:
THAKUR, Raghu Raj Singh,JONES, David,SOLIMAN, Karim,SONAWANE, Rahul,WANG, Yujing
申请号:
EPEP2019/086834
公开号:
WO2020/128067A1
申请日:
2019.12.20
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
The present invention relates to an ocular implant for the controlled release of a therapeutic agent or drug comprising: a) at least 0.1% w/w of a therapeutic agent; b) 5 to 95% w/w of a crosslinked polymer matrix; c) and 0.1 to 40% w/w of a biodegradable polymer selected from the group consisting of lactide/glycolide copolymer (including poly(lactide-co-glycolide) (PLGA)), poly (L-lactide) (PLA), polyhydroxyalkanoates, including polyhydroxybutyrate, polyglycolic acid (PGA), polycaprolactone (PCL), poly (DL-lactide) (PDL), poly (D-lactide), lactide/caprolactone copolymer, poly-L-lactide-co-caprolactone (PLC) and mixtures, copolymers, and block copolymers thereof;wherein the crosslinked polymer matrix is obtained by crosslinking a photopolymerizable composition selected from the group consisting of fragments or monomers of polyalkylene glycol mono-acrylate, polyalkylene glycol diacrylate, polyalkylene glycol mono-methacrylate and polyalkylene glycol dimethacrylate, and mixtures, copolymers, and block copolymers thereof, characterized in that the ocular implant is at least partially coated on its external surface with at least one coating layer selected from the group consisting of lactide/glycolide copolymer (including poly(lactide-co-glycolide) (PLGA)), poly (L-lactide) (PLA), polyhydroxyalkanoates, including polyhydroxybutyrate, polyglycolic acid (PGA), polycaprolactone (PCL), lactide/caprolactone copolymer, poly (DL-lactide) (PDL), poly (D-lactide), poly-L-lactide-co-caprolactone (PLC) and mixtures, copolymers, and block copolymers thereof; crosslinked fragments or monomers of polyalkylene glycol mono-acrylate, polyalkylene glycol diacrylate, polyalkylene glycol methacrylate and polyalkylene glycol dimethacrylate, and mixtures, copolymers, and block copolymers thereof.La présente invention concerne un implant oculaire pour la libération contrôlée d'un agent thérapeutique ou d'un médicament comprenant : a) au moins 0,1 % en poids d'un agent thérapeutique ; b) 5 à 9
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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