An endoscope system has an image pickup section and a processor. The image pickup section has a control register section which controls a sensor section, a nonvolatile memory which stores first setup data, a control signal interface section which sets the first setup data in the control register section, and an initialization check register which senses an abnormality in the control register section. When an abnormality is sensed, the control signal interface section reads out the setup data from the nonvolatile memory and performs control so as to reset the setup data in the control register section. The control signal interface section further has a memory which stores reset occurrence information upon occurrence of reset. The processor includes a control section which reads out the reset occurrence information from the memory, and, when reset is detected, transmits second setup information held by the processor to the image pickup section.