Indiana University Research and Technology Corporation
发明人:
Smiley, David L.,Chabenne, Joseph,Dimarchi, Maria,Dimarchi, Richard D.,Day, Jonathan
申请号：
AU2009260301
公开号：
AU2009260301B2
申请日:
2009.06.16
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
Modified glucagon peptides are disclosed having improved solubility and/or half-life while retaining glucagon agonist activity. The glycogen peptides have been modified by substitution of native amino acids with, and/or addition of, charged amino acids to the carboxy terminus of the peptide. The modified glucagon agonists can be further modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 23, or both to further enhance the solubility of the glucagon agonist analogs.
