The present invention provides a stent with multi drug-coatings including a stent body and active drugs. A portion of surface or whole surface of the stent body is covered with at least one kind and at least one layer of active drug coating. The utilization of the present invention can not only accelerate endothelialization of coronary, but also resist cell proliferation, resist the migration of smooth muscle cells, reduce the formation of thrombus and the inflammatory reaction of cells and recover the flexibility of vascular tissues. Multi drug-coatings can prevent the multiple phases of the happening of restenosis, resist the release of drugs at different phases of endothelial repair and play the role of co-resisting the vessel stent restenosis by many kinds of drugs. Well-composed multi drug-coatings make the coating area and coating layers of drug-eluting stent and drugs compatibility more reasonable, and make the use of drug-eluting stent more secure and bring better effect of treatment.
