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DERMATOLOGICAL, PHARMACEUTICAL COMPOSITION SUITABLE FOR OLIGONUCLEOTIDES
专利权人:
ШТЕРНА БИОЛОГИКАЛС ГМБХ энд КО. КГ (DE)
发明人:
ШМИДТС Томас (DE),ГАРН Хольгер (DE),РУНКЕЛЬ Франк (DE)
申请号:
RU2012137904/15
公开号:
RU2012137904A
申请日:
2011.02.11
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A topical pharmaceutical composition comprising at least one lipophilic emulsifier, at least one thickening agent, at least one occluding agent, or alternatively synthetic or natural oil or wax, at least one inorganic and / or organic additive, and at least at least one oligonucleotide. 2. The pharmaceutical composition according to claim 1, containing at least one hydrophilic emulsifier and / or at least one amphiphilic component. The pharmaceutical composition according to claim 1, containing at least one moisture retention agent and / or one preservative. The pharmaceutical composition according to claim 1, wherein the lipophilic emulsifier is selected from the group consisting of sorbitan fatty acid esters, glycerol derivatives (e.g., Spans, as well as glycerol stearate, glycerol dioleate, glycerol monooleate), and the hydrophilic emulsifier is selected from the group consisting of polysorbates or ethoxylated (such as twins, stearates, laurates, cetearates) or ethoxylated ethers or esters. 5. The pharmaceutical composition of claim 1, wherein the inorganic and / or organic additive comprises a salt or ionic liquid. The pharmaceutical composition according to claim 5, wherein the salt contains cations of Na, Mg, K, Li, Ca, Fe, Cu, Ag, or a combination of these elements. The pharmaceutical composition of claim 5, wherein the ionic liquid contains a combination of elements with organic cations. The pharmaceutical composition according to claim 2, wherein the at least one hydrophilic emulsifier is selected from the group consisting of polysorbates or ethoxylated polyethylene glycols (such as twins, stearates, laurates, cetearates) or1. Фармацевтическая композиция для местного применения, содержащая по меньшей мере один липофильный эмульгатор, по меньшей мере один загуститель, по меньшей мере один окклюзирующий агент или альтернативно синтетическое или натуральное масло или воск, по меньшей мере одну неорганическую и/или органическую добавку и по меньшей мере один
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