Jacki Lin,Ralph Arlinghaus,Tong Sun,Lin Ji,Bulent Ozpolat,Gabriel Lopez-Berestein,Jack A. Roth
申请号：
US13720621
公开号：
US08859727B2
申请日:
2012.12.19
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A nanoparticle-polypeptide complex comprising a bioactive polypeptide in association with a nanoparticle, wherein the bioactive polypeptide is modified by the addition of a chemical moiety that facilitates cellular uptake of the protein. The polypeptide can be a protein or a peptide. In some embodiments, the amino acid sequence of the protein or peptide is derived from the amino acid sequence of a tumor suppressor gene product.
