A system (3010) for removal of a tissue specimen from an internal body cavity includes a cannula arrangement having an access cannula (3100) including a first elongated tubular member, a deployment cannula (3200) including a second elongated tubular member configured for insertion into the first lumen, a deployment plunger (3400) including a proximal base (3410) and a plurality of engagement arms (3430) extending distally from the proximal base, and an inner cannula (3500) including a third elongated tubular member. The system further includes a containment bag (3300) selectively deployable from the cannula arrangement. Distal advancement of the deployment cannula (3200) relative to the access cannula deploys a first portion of the containment bag (3300) from the cannula arrangement, and distal advancement of the deployment plunger (3400) relative to the deployment cannula (3200) and the access cannula (3100) deploys a second portion of the containment bag (3300) from the cannula arrangement.
