THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY
发明人:
申请号：
EP08743288.6
公开号：
EP2150274B1
申请日:
2008.04.25
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
Shigella vaccine strains whose primary attenuating feature is deletion of the virG(icsA) gene and additional two or more deletions in setAB(shET1), senA(shET2), senB(shET2-2), stxAB, and msbB2 genes. Thus, the vaccine strain will have three or more deletions in the identified genes, will be safer, and will reduce or eliminate symptoms of fever and diarrhea in humans. The following specific vaccine strains have been constructed: WRSS3 (&Dgr；senA, &Dgr；senB, &Dgr；virG, &Dgr；msbB2), WRSf2G15 (&Dgr；virG, &Dgr；setAB, &Dgr；senA, &Dgr；senB, &Dgr；msbB2), and WRSd5 (&Dgr；virG, &Dgr；stxAB, &Dgr；senA, &Dgr；senB, &Dgr；msbB2).
