The present invention is directed to a monoclonal antibody that recognizes human CD63 in its native form. The invention is also directed to a hybridoma cell line that produces the monoclonal antibody, and to methods of diagnosing and treating cancer and purifying exosomes using the antibody.La présente invention concerne un anticorps monoclonal qui reconnait CD63 humain dans sa forme native. Linvention concerne également une lignée cellulaire dhybridomes produisant lanticorps ainsi que des procédés permettant le diagnostic et le traitement du cancer et la purification dexosomes à laide de lanticorps.