Michael Kock,Thomas Höger,Burkhard Kröger,Bernd Otterbach,Wilfried Lubisch,Hans-Georg Lemaire
申请号：
US12778692
公开号：
US09051553B2
申请日:
2010.05.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which hasa) a functional NAD binding domain andb) no zinc finger sequence motif of the general formulaCX2CXmHX2Cin whichm is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid；and the functional equivalents thereof； nucleic acids coding therefor； antibodies with specificity for the novel protein； pharmaceutical and gene therapy compositions which comprise products according to the invention； methods for the analytical determination of the proteins and nucleic acids according to the invention； methods for identifying effectors or binding partners of the proteins according to the invention； novel PARP effectors； and methods for determining the activity of such effectors.
