LIM, FLORENCIA,NGO, MICHAEL HUY,TANG, YIWEN,HOSSAINY, SYED F. A.,TROLLSAS, MIKAEL O.
申请号：
ES08845756
公开号：
ES2500540T3
申请日:
2008.10.23
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
An implantable device comprising a coating comprising a composition, where the coating has a thickness of <；= 6 microns and is completely degraded, which means the loss of at least 95% of its mass, or is substantially completely degraded , which means the loss of at least 75% of its mass, in 12 months when exposed to physiological conditions, where the composition comprises a biodegradable block copolymer, where the copolymer: is derived from at least two polar monomers selected from glycolide (GA), D-lactide (DLA), L-lactide (LLA), D, L-lactide (DLLA) and meso-lactide (MLA) and at least one non-polar monomer selected from valerolactone (VL), caprolactone ( CL), trimethylene carbonate (TMC), dioxanone (DS), hydroxybutyrate (HB), and hydroxivalerate (HV)； it has a Tg of -150 ° C at 100 ° C； it has a polymeric average molecular weight (Mn) of 10 kDa to 500 kDa； and it degrades completely, which means the loss of at least 95% of its mass, or it degrades substantially completely, which means the loss of at least 75% of its mass, in 12 months； and where: each type of monomer independently has 10 to 5,000 units in the copolymer； and the mole% of each type of monomer is independently from 5% to 90%.Un dispositivo implantable que comprende un revestimiento que comprende una composición, donde el revestimiento tiene un grosor de <；= 6 micrones y se degrada completamente, lo que significa la pérdida de al menos el 95% de su masa, o se degrada sustancialmente de manera completa, lo que significa la pérdida de al menos un 75% de su masa, en 12 meses cuando se expone a condiciones fisiológicas, donde la composición comprende un copolímero en bloque biodegradable, donde el copolímero: se deriva de al menos dos monómeros polares seleccionados entre glicólido (GA), D-láctido (DLA), L-láctido (LLA), D,L-láctido (DLLA) y meso-láctido (MLA) y al menos un monómero no polar seleccionado entre valerolactona (VL), caprolactona (CL), carbonato de trimetileno (TMC), dioxanona (DS), hidr
