Maria del Carmen CARMONA OROZCO,Andrés Montefeltro,Gabriel Alvarado Urbina,Analía Bortolozzi Biassoni,Raquel Revilla-Sanchez
申请号：
US14064047
公开号：
US20140315795A1
申请日:
2013.10.25
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides a conjugate comprising (i) a nucleic acid which is complementary to a target nucleic acid sequence and which expression prevents or reduces expression of the target nucleic acid and (ii) a selectivity agent which is capable of binding with high affinity to a receptor which can be internalised by the cell in response to the binding of said selectivity agent. The conjugates of the present invention are useful for the delivery of the nucleic acid to a cell of interest and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of contrast agents to the cells for diagnostic purposes.
