Provided herein are compositions containing compounds, or pharmaceutically acceptable salts, that metabolize to monomethyl fumarate with certain pharmacokinetic parameters and methods for treating, prophylaxis, or amelioration of neurodegenerative diseases including multiple sclerosis using such compositions in a subject, wherein if the compositions contain dimethyl fumarate, the total amount of dimethyl fumarate in the compositions ranges from about 43% w/w to about 95% w/w.本發明提供含有可代謝成反式丁烯二酸單甲酯之化合物或醫藥學上可接受之鹽且具有某些藥物動力學參數的組成物以及使用該組成物以治療、預防或改善個體之包括多發性硬化之神經退化性疾病的方法，其中若該組成物含有反式丁烯二酸二甲酯，則該組成物中反式丁烯二酸二甲酯之總量介於約43% w/w至約95% w/w。
