DIXON, DARRYL DAVID,GRINA, JONAS,JOSEY, JOHN A.,RIZZI, JAMES P.,SCHLACHTER, STEPHEN T.,WALLACE, ELI M.,WANG, BIN,WEHN, PAUL,XU, RUI,YANG, HANBIAO
申请号：
CA2931085
公开号：
CA2931085A1
申请日:
2014.12.15
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present disclosure relates to cyclic sulfones and sulfoximines that are HIF-2a inhibitors and methods of making and using them for treating cancers. In another aspect, the present disclosure provides a pharmaceutical composition comprising a compound described herein and a pharmaceutically acceptable carrier or excipient. The compound may exist in an amorphous form, a crystalline form, or as a salt, solvate, or hydrate. In another aspect, the present disclosure provides a method of treating renal cell carcinoma by administrating a therapeutically effective amount of a compound described herein or a pharmaceutical composition thereof to a subject in need of such treatment.
