A process for the preparation of a pharmaceutical composition comprising pyrogenically produced silicon dioxide as a glidant for pharmaceutical active constituents and/or auxiliary substance comprising the following steps: de-aerating or decompressing the pyrogenically produced silicon dioxide compressing (compacting) the pyrogenically produced silicon dioxid by roller compaction to band-like intermediates (Schulpen) to have a tamped density (according to DIN EN ISO 787-11) of from 185 to 700 g/1 breaking the band-like intermediates(Schulpen) optionally grading or sieving the broken band-like intermediates(Schulpen) - combining the broken band-like intermediates (Schulpen) with at least one pharmaceutically active constituent.
