The Johns Hopkins University;Kennedy Krieger Institute, Inc.
发明人:
Rangaramanujam, Kannan,Kannan, Sujatha,Nance, Elizabeth,Blue, Mary E.,Johnston, Michael V.,Baumgartner, William,Zhang, Fan,Wilson, Mary Ann,Slusher, Barbara
申请号：
AU2015301579
公开号：
AU2015301579B2
申请日:
2015.08.13
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
A dendrimer formation, such as a PAMAM dendrimer or a multiarm PEG polymeric formulation has been developed for systemic administration to the brain or central nervous system. In the preferred embodiment, the dendrimers are in the form of dendrimer nanoparticles comprising poly(amidoamine) (PAMAM) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, prophylactic or diagnostic agent for treatment of one or more symptoms of neurodegenerative, neurodevelopmental or neurological disorders such as Rett syndrome or autism spectrum disorders, D6 generation dendrimers provide significantly enhanced uptake into areas of brain Injury, providing a means for diagnosis as well, as drug delivery.
