COMPOSITION PHARMACEUTIQUE CONTENANT DES CELLULES SOUCHES MÉSENCHYMATEUSES POSITIVES À ROR1 DANS LE TRAITEMENT PROPHYLACTIQUE OU THÉRAPEUTIQUE D'UNE MALADIE ASSOCIÉE À LA FIBROSE, SON PROCÉDÉ DE PRÉPARATION, ET PROCÉDÉ DE TRAITEMENT PROPHYLACTIQUE OU THÉRAPEUTIQUE D'UNE MALADIE ASSOCIÉE À UNE FIBROSE À L'AIDE DE CELLULES SOUCHES MÉSENCHYMATEUSES POSITIVES À ROR1
The purpose of the present invention is to provide the following: novel mesenchymal stem cells having an excellent therapeutic effect on various diseases, particularly diseases associated with fibrosis； and a pharmaceutical composition containing such mesenchymal stem cells. The present invention is a therapeutic agent for fibrosis that contains ROR1-positive mesenchymal stem cells and/or a culture supernatant thereof and that is for preventing or treating a disease associated with fibrosis. The mesenchymal stem cells are CD29-, CD73-, CD90-, CD105-, and CD166-positive and are preferably derived from the umbilical cord or fat. In addition, the abovementioned disease associated with fibrosis is preferably a liver disease, a lung disease, a kidney disease, or a heart disease.
