Methods for the treatment of peripheral neuropathy are provided which include applying a topical composition to a peripheral appendage of a subject in need of such treatment. The topical composition includes a B1 vitamer, a B6 vitamer, and a B9 vitamer in a dermatologically acceptable carrier. The methods are effective in preventing further degeneration and/or restoring epidermal nerve fiber density (ENFD) in patients with peripheral neuropathy, and in preventing or alleviating neuropathic pain.
