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Method for using folate in the preparation of a formulation suitable for the prevention and treatment of inflammation and inflammation-related diseases, in particular suitable for affecting the inflammation markers CRP and SAA
专利权人:
メルック・エプロバ・アクチエンゲゼルシヤフト
发明人:
ミュラー・トーマス・エフ,モゼル・ルドルフ,ウルマン・マルチン
申请号:
JP2003570842
公开号:
JP5433125B2
申请日:
2003.02.24
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
This invention relates to the use of folates for producing a pharmaceutical preparation suitable for the prevention and treatment of inflammation and of diseases associated with inflammation, particularly for influencing the inflammation markers C-reactive protein (CRP) and serum amyloid A protein (SAA). The clinical areas of application are all anomalies of the CRP and SM levels. The invention also relates to pharmaceutical preparations for the prevention and treatment of inflammation and of diseases associated with inflammation, particularly for influencing CRP and SM levels, characterised in that as an active ingredient it comprises at least one compound which is selected from the group consisting of pteroic acid monoglutamate (folic acid), dihydrofolic acid, 5-formyltetrahydrofolic acid, 5-methyltetrahydrofolic acid, 5,10-methylenetetrahydrofolic acid, 5,10-methenyl-tetrahydrofolic acid, 10-formyltetrahydrofolic acid or tetrahydrofolic acid, polyglutamates thereof, optical isomers thereof, particularly optically pure natural isomers thereof, and mixtures of optical isomers also, particularly racemic mixtures, as well as pharmaceutically acceptable salts thereof also, together with pharmaceutically acceptable active ingredients and adjuvants.
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