Rafael Piestun,Hengyi Ju,Jacob Dove,Antonio Miguel Caravaca-Aguirre,Todd Murray,Donald Conkey
申请号：
US14913958
公开号：
US10036735B2
申请日:
2014.08.26
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Systems and methods are disclosed to enhance three-dimensional photoacoustic imaging behind, through, or inside a scattering material. Some embodiments can increase the optical fluence in an ultrasound transducer focus and/or enhance the optical intensity using wavefront shaping before the scatterer. The photoacoustic signal induced by an object placed behind the scattering medium can serve as feedback to optimize the wavefront, enabling one order of magnitude enhancement of the photoacoustic amplitude. Using the enhanced optical intensity, the object can be scanned in two dimensions and/or a spot can be scanned by re-optimizing the wavefront before post-processing of the data to reconstruct the image. The temporal photoacoustic signal provides information to reconstruct the third-dimensional information.
