The present invention relates to a device, comprising: an agent carrier comprising an agent transfer surface for delivery of an agent into a tissue, wherein the agent carrier comprises or is acoustically couplable to a piezoelectric substrate； an electrode electrically couplable to the piezoelectric substrate； and a controller electrically couplable to the electrode and configured to apply an electrical signal to the electrode to propagate an acoustic wave on and/or in the piezoelectric substrate which is capable of delivering the agent from the device into the tissue. Methods of using the device for non-invasive delivery of agents into target tissues are also disclosed.
