VIB vzw;Universiteit Gent;Katholieke Universiteit Leuven, K.U. Leuven R & D; K.U. Leuven R & D;Katholieke Universiteit Leuven
发明人:
Baens, Thijs,Beyaert, Rudi,Heyninck, Karen,Marynen, Peter
申请号：
AU2008327884
公开号：
AU2008327884B2
申请日:
2008.11.20
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The present invention relates to inhibitors of MALT1 proteolytic and/or autoproteolytic activity. More specifically, it relates to compounds such as, but not limited to peptide derivates such as Z-LSSR-CHO, Z-LSSR-CMK, Z-GASR-CHO, and Z-GASR-CMK, and small compounds such as 5-{[5-(3-chloro-4-methylphenyl)-2-furyl]methylene}-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione and variants thereof, and the use of those compounds for the preparation of a medicament. The invention relates further to a method to screen for inhibitors of the MALT1 proteolytic and/or autoproteolytic activity.
