A pre-packaged hormone delivery system and method are provided for administering bioidentical human hormones using a combination of modalities for the treatment of human physiological conditions. A combination of indoles, glutathione, methylating agents, glucuronidating agents, sulfating agents, acetylating agents and glutathione are used in combination with bio-identical progesterones and estrogens to safely remove the estrogen from the system as a standard step in the hormone treatment system process.