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Enteric coated granule and method for preparing the same
专利权人:
Mutsunori Tanji
发明人:
Mutsunori Tanji,Tadashi Matsui,Shuichiro Yuasa,Yuichi Nishiyama,Yuichi Ito,Ikuo Fukui
申请号:
US11764084
公开号:
US09095513B2
申请日:
2007.06.15
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention is an enteric coated granule having controlled dissolution in water even at a small coating amount and a preparation method thereof. More specifically, provided are an enteric coated granule comprising a raw granule or a granule comprising a raw granule and at least one layer covering the raw granule, a first enteric layer covering the raw granule or the granule, and a second enteric layer formed over the first enteric layer, wherein the first and the second enteric layers comprise a first and a second hydroxypropylmethyl cellulose acetate succinates (HPMCASs) different in solubility pH, respectively, and the solubility pH value of the second HPMCAS of the second enteric layer is lower than that of the first enteric layer and a preparation method comprising steps of covering a raw granule or a granule comprising a raw granule and at least one layer covering the raw granule with an enteric coating agent comprising a first HPMCAS to form a first enteric layer and forming, over the first enteric layer, a second coating layer by using a second enteric coating agent comprising a second HPMCAS having a lower solubility pH value than that of the first HPMCAS.
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