Provided is an agent that reduces the risk of disease onset resulting from non-dipper type intra-day blood pressure fluctuations and that can reduce the onset of disease resulting from intra-day blood pressure fluctuation risk and prone to occur towards the morning when early morning systolic blood pressure significantly decreases from that of the night time in humans having a particular non-dipper type intra-day blood pressure fluctuation pattern, particularly healthy individuals exhibiting normal SBP and DBP values. The agent is characterized by containing: a hydrolysate containing VPP and IPP and obtained by hydrolyzing animal milk protein； or a concentrate thereof.本發明係提供以具有特定的Non-dipper型血壓一日內變動模式的人，尤其顯示SBP及DBP為正常值的健康人為對象，可有效地降低夜晚至清晨的收縮壓，可減輕早上容易發病，血壓一日內變動風險所導致的疾病發病降低之Non-dipper型血壓一日內變動的疾病發病風險用劑。本發明之降低用劑係以含有水解獸乳蛋白質而得之包含VPP及IPP之水解物或其濃縮物為特徵。
