The present invention relates to glucagon-like peptide-1 (GLP-1), GLP-1 fragment, GLP-1 secretion increase promoter, GLP-1 degradation inhibitor, GLP-1 receptor (GLP-1R) enhancer, or exendin The present invention relates to a pharmaceutical composition for preventing or treating muscular atrophy or muscular atrophy comprising -4, and a method for treating muscular atrophy or myopathy using the pharmaceutical composition. When the pharmaceutical composition for preventing or treating muscular atrophy or sarcopenia provided by the present invention is administered to an individual who has developed muscular atrophy or sarcopenia, the weight decreased due to muscular atrophy or sarcopenia, Since the expression level of genes involved in skeletal muscle weight, grip strength and muscle generation can be restored to a normal state, it will be widely used in the development of effective therapeutic agents for muscle atrophy or myopathy. [Selection] FIG.本発明はグルカゴン類似ペプチド‐1(GLP-1)、GLP-1断片、GLP-1分泌増加促進剤、GLP-1分解抑制剤、 GLP-1受容体(GLP-1R)亢進剤、またはエクセンディン-4を含む筋萎縮症または筋減少症の予防または治療用薬学組成物及び前記薬学組成物を用いて筋萎縮症または筋減少症を治療する方法に関する。本発明で提供する筋萎縮症または筋減少症の予防または治療用薬学組成物を筋萎縮症または筋減少症が発病された個体に投与すると、筋萎縮症または筋減少症により減少された体重、骨格筋の重量、握力及び筋肉生成に関与する遺伝子の発現レベルを正常状態に回復させうるため、効果的な筋萎縮症または筋減少症の治療剤の開発に広く活用されるだろう。【選択図】 図3