In the treatment of various diseases, including diabetes (type 1 and / or 2) and diabetes related diseases or diseases, use mixed therapy. Pharmaceutical ingredients. Claim 1 has the formula (1): r1-z8336a-l8336a-y8336a-r2 (1), wherein R1 is h and asphalt c83218331；2. Acetyl, thyroid, benzoic acid or trifluoroethane； R2 is oh o nh482222；a. 22 2-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-11 11 11 11 1U； Z: Lys, Arg and ORN； Z: Gln and Tyr； Z 1 830808； a. From met to Leu； z18310 from Glu, Arg, ORN, Cys and Lys； z2830404 from Arg, Lys and ORN； z283808 from Arg, ORN, Lys and Glu； z283099 from Trp, Lys, Cys and Phe； z283211 from Lys, Arg and ORN； z283212 from ASN and ASP；L833636 is a cucumber sequence, the formula is (1b) 1-l23-l83088 (1b), in which L1 is selected or absent from on, 8ado, Cys, Lys and Gln； L2 is selected or absent from on, 8ado, Cys, Lys and Gln； L3 is selected or absent from ORN, 8ado, Cys, Lys and Gln； l8308ons is selected or absent from Cylons； e. Ys and glno are absent； y8336 is a formula with formula (1c): y12-y13-y18308a-y18309a-y18309a-asp-y18311a (1c), where y1222 is selected from Tyr and ALA or not； Y13 is selected from Gly and ALA or not； y18308se is selected from Trp, 1nal and Phe； y1830999 is selected from Petr, nlee；E y1-8311 is selected from phe-3 - (3-pyridine)； in alachlor, at least one (1a) and (1b) matched Lys, ORN or Cys substitute is combined with an aliphatic and / or biological substitute and / or adhesive； or a salt or solution acceptable for drugs.Conjugados peptídicos, y uso de los conjugados en el tratamiento de diversas enfermedades o trastornos, que incluyen la diabetes (de tipo 1 y/o tipo 2) y enfermedades o trastornos relacionados con la diabetes. Composición farmacéutica. Reivindicación 1: Un conjugado peptídico caracterizado porque tiene la fórmula (1): R¹-Zₐ-Lₐ-Yₐ-R² (1) en donde R¹ es H, alquilo C₁₋₄, acetilo, formilo, benzoilo o trifluoroacetilo； y R² es OH o NH₂； Zₐ es una secuencia peptídica que tiene la fórmula (1a): His-Gly-GI
