KIM, Jung Kuk,LEE, Jong Min,KIM, Sang Yun,BAE, Sung Min,JUNG, Sung Youb,KWON, Se Chang
申请号：
PE0011682017
公开号：
PE11542017A1
申请日:
2015.12.30
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Refers to a Derivative of glucagon, which comprises the sequence of amino acids of formula I and which has improved Physical Properties due to an isoelectric Point (PL) different from the native glucagon: X1 - X2 - qgtf X7 - - - - - sdys X12, X13 x14x x16 x15 - - - - - - X17 x18 x19 - X20 X21 - F - X23 x24 - W - L - - - T (x27 X28 formul 1) in general, where X1 is Adiuretin: histidine, histidine,Among others x2 is acid Alpha Methyl aminoisobutirico glutamic acid (AIB), among others X7 is threonine or Valine, Lysine or cysteine is X12, X13 is tyrosine and cysteine, Leucine or x14 is x15 is cysteine, Aspartic acid, glutamic acid and cysteine x16 is glutamic acid, Aspartic acid, between another S x17 is Aspartic acid, glutamine, among others x18 is Aspartic acid, glutamine,Among others, x19 is alanine, cysteine, X20 is Lysine, glutamic acid, among others X21 is Aspartic acid, glutamic acid, Valine and arginine is X23 x24 is Valine, Leucine, isoleucine or x27 is among others methionine X28 is arginine asparagine (or with the condition that when the am sequence Inoacidos of formula I is identical to the SEQ ID no: 1, is excluded).It also relates to a Pharmaceutical composition. The derivative is useful in the treatment of ObesitySe refiere a un derivado del glucagon, que comprende la secuencia de aminoacidos de formula I y que tiene propiedades fisicas mejoradas debido a un punto isoelectrico (pl) diferente a la del glucagon nativo: X1-X2-QGTF-X7-SDYS-X12-X13-X14X-X15-X16-X17-X18-X19-X20-X21-F-X23-X24-W-L-X27-X28-T (Formula General 1), donde: X1 es histidina, desamino-histidina, entre otros X2 es acido alfa-metil-glutamico, acido aminoisobutirico (Aib), entre otros X7 es treonina o valina X12 es lisina o cisteina X13 es tirosina o cisteina X14 es leucina o cisteina X15 es acido aspartico, acido glutamico o cisteina X16 es acido glutamico, acido aspartico, entre otros X17 es acido aspartico, glutamina, entre otros X18 es acido aspartico, glutamina, entre otros X19 es alan
