Nikolova, Zariana,Cho, Robert,Stafford, Jeffrey Alan
申请号：
AU2016379347
公开号：
AU2016379347A1
申请日:
2016.12.20
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present disclosure relates generally to compositions and methods of treating cancers, such as glioblastoma and non-Hodgkin's lymphomas, or other cancers in which the subject suffers from an advanced solid tumor, comprising the administration of a bromodomain and extra-terminal protein (BET) inhibitor and at least one chemotherapeutic agent, which does not inhibit BET directly. The BET inhibitor/chemotherapeutic agent combination therapy can yield synergistic effects, thereby increasing the effectiveness of the cancer treatment as compared to the administration of either the BET inhibitor or the chemotherapeutic agent alone.
