METHOD OF TARGETING SPECIFIC CELL POPULATIONS USING CELL-BINDING AGENT MAYTANSINOID CONJUGATES LINKED VIA NON-CLEAVABLE LINKER, SAID CONJUGATES, AND METHODS OF MAKING SAID CONJUGATES
PROBLEM TO BE SOLVED: To provide a method of delivering highly cytotoxic maytansinoid to target cell populations such as tumor cells.SOLUTION: Cell-binding agent-maytansinoid conjugates are obtained by covalently linking a cell-binding agent to a maytansinoid derivative modified with a sulfur-free non-cleavable linker represented by formula 7. Also provided is a method of delivering maytansinoid to target cell populations using the conjugates. (R is H or SONa)SELECTED DRAWING: None【課題】高い細胞毒性のあるメイタンシノイドを、腫瘍細胞等の標的細胞集団に送達する方法の提供。【解決手段】式7に代表される硫黄を含有しない非開裂リンカーで修飾したメイタンシノイド誘導体と細胞結合物質とを共有結合させて得られる細胞結合物質-メイタンシノイド複合体、及び前記複合体を用いるメイタンシノイドの標的細胞集団への送達方法。(RはH又はSO3Na+)【選択図】なし