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DERIVES PEPTIDIQUES ET DERIVES DE MIMETIQUES PEPTIDIQUES AYANT DES PROPRIETES II D'INHIBITION DE L'INTEGRINE
专利权人:
MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
发明人:
MEYER, JORG,NIES, BERTHOLD,DARD, MICHEL,HOLZEMANN, GUNTER,KESSLER, HORST,KANTLEHNER, MARTIN,HERSEL, ULRICH,GIBSON, CHRISTOPH,SULYOK, GABOR
申请号:
CA2419469
公开号:
CA2419469C
申请日:
2001.08.02
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The invention relates to compounds of formula (I) B-Q-X1, wherein B is abioactive, cell adhesive mediating molecule, selected from the group (i) andThr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (ii), Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (iii), Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (iv), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg (v), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn (vi), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg (vii), wherein (i) X, Y, Z,R2, R3, R4, A, Ar, Hal, Het, Het1, n, m, o, p, q, s, t have the meanings citedin Claim 1, Q is absent or is an organic spacer molecule, X1 is an anchormolecule selected from the group cited in Claim 1, and the salts thereof,which can be used as integrin inhibitors particularly for treatment ofillnesses, deficiencies and inflammations caused by implants and osteolyticillnesses such as osteoporosis, thrombosis, cardiac infarction andarteriosclerosis, in addition to the acceleration and strengthening of theintegration process of implants or the biocompatible surface in tissue.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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