A pharmaceutical combination of memantine and a non-anticholinergic antiemetic agent for the treatment of hypocholinergic disorders in further combination with high doses of donepezil and with solifenacin, and kits comprising said combination. A pharmaceutical combination of memantine and solifenacin for the treatment of hypocholinergic disorders, including Alzheimer type dementia, in further combination with high doses of donepezil, and kits comprising said combination.本發明係關於美金剛胺(memantine)與非抗膽鹼激導性止吐劑(non-anticholinergic antiemetic agent)的醫藥組合，其用於進一步與高劑量之多奈哌齊(donepezil)及與索非那新(solifenacin)以組合形式治療膽鹼能過低病症；及包含該組合之套組。本發明提供一種美金剛胺與索非那新之醫藥組合，其用於進一步與高劑量之多奈哌齊以組合形式治療膽鹼能過低病症，包括阿茲海默症(Alzheimer)型癡呆；及包含該組合之套組。
