Dymek, Barbara,Zagozda, Marcin,Wieczorek, Maciej,Dubiel, Krzysztof,Stanczak, Aleksandra,Zdzalik, Daria,Gunerka, Pawel,Sekular, Mariola,Dziachan, Maciej
申请号：
HRP20192195
公开号：
HRP20192195T1
申请日:
2019.12.06
申请国别(地区):
HR
年份:
2020
代理人:
摘要：
A compound of the general formula (I) wherein Y represents -CH2- or >；C=0； R1 is selected from the group consisting of A1, A2 and A3； R2 represents dioxothiomorpholino moiety B1, piperazinyl moiety B2, azetidinyl moiety B3, or piperidinyl moiety B4； R3 is selected from the group consisting of H, halogen, and C1 -C4 alkyl； R4 is selected from the group consisting of C1 -C4 alkyl, C3-C4- cycloalkyl, C1 -C4 alkyl substituted with C1 -C4 alkoxy, and CHF2, and their pharmaceutically acceptable salts. Pharmaceutical compositions comprising said compounds and their use in the treatment of diseases of immune system, inflammatory diseases and cancer.
