The embodiment described herein are related nanoemulsions comprising botulinumtoxins. In one embodiment, the nanoemulsions are prepared by high pressuremicrofluidization and comprise a particle size distribution exclusivelybetween 10 and 300 nm. The nanoemulsions contemplated by the present inventionare useful for the cosmetic and medical treatment of muscular contracturestates. For example, botulinum toxin may relax facial muscles such that skinwrinkles become smoother and less noticeable. Further, the present inventioncontemplates a cosmetic formulation that may be self-administered, forexample, in the privacy of one's home and without medical supervision.
