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Anthranilic acid derivatives
专利权人:
Leif Svenson;Helén Tuvesson Andersson;Ingrid Hallin;Ingela Fritzson;Ulf Vellmar
发明人:
Helén Tuvesson Andersson,Ulf Vellmar,Ingrid Hallin,Leif Svenson,Ingela Fritzson
申请号:
US12535358
公开号:
US08263658B2
申请日:
2009.08.04
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Compounds of formula (I) are provided, wherein X is CH═CH, CH2O wherein the oxygen atom is bound to ring B, or OCH2 wherein the oxygen atom is bound to ring A; Y is hydrogen, straight or branched C1-C6 alkyl or a pharmaceutically acceptable inorganic cation; R1 is ethyl or cyclopropyl; and R2 and R3 are the same or different and are selected from F, Cl, Br, CF3 and OCF3. The compounds are useful for the treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection, and malignant neoplasia. Pharmaceutical compositions comprising the compounds, methods of using the compounds, and methods for preparing the compounds are also provided.
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