COMPOSES HETEROAROMATIQUES ET LEUR UTILISATION COMME LIGANDS DU RECEPTEUR D1 DE LA DOPAMINE

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专利权人:

PFIZER;Pfizer Inc.

发明人:

申请号：

EP13820922.6

公开号：

EP2917219B1

申请日:

2013.10.29

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The present invention provides D1 agonists with reduced D1R desensitization, D1 agonists with a reduced ²-arrestin recruitment activity relative to Dopamine, D1 agonists interacting significantly with the Ser188 but not significantly with the Ser202 of a D1R when binding to the D1R, D1 agonists interacting less strongly with the Asp103 and interacting less strongly with the Ser198 of a D1R when binding to the D1R, and their uses.

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中国工程科技知识中心

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http://www.ckcest.cn/home/