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IMMUNIZATION PROTOCOL FOR DIRECTED EXPANSION AND MATURATION
专利权人:
Novartis AG
发明人:
Philip Dormitzer
申请号:
US15378456
公开号:
US20170189502A1
申请日:
2016.12.14
申请国别(地区):
US
年份:
2017
代理人:
摘要:
A first antigen is administered to a subject to select progenitor B cells that are suitable for subsequent production of a desirable affinity-matured antibody, and then a second antigen is administered to stimulate the expansion of B cells that produce that affinity-matured antibody. An immunization protocol is used in which two different antigens are administered (usually in series, but in some embodiment simultaneously), where the first antigen elicits an efficient germline antibody response and the second antigen elicits an efficient and desired affinity-matured antibody response.
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