A microparticle (options), its composition including (options), a food, pharmaceutical, therapeutic cosmetic or nutraceutical product based on them, a method for preparing an immunomodulating composition with their help and a method for producing said microparticle
Сентро насиональ де текнолохия и сегуридад алиментария, Лабораторио дель Эбро (ES);Универсидад де Наварра (ES); Лабораторио дель Эбро (ES);Сентро насиональ де текнолохия и сегуридад алиментария
1. A microparticle, including a matrix consisting of casein and chitosan in a weight ratio of chitosan to casein of 1: 5 ÷ 150, and a probiotic bacterium. 2. The microparticle according to claim 1, which further comprises a crosslinking agent. A microparticle according to claim 2, wherein said crosslinking agent is a divalent metal cation selected from the group consisting of Ca, Mg, Zn, Fe, and combinations thereof, tripolyphosphate, vanillin, genipine, and combinations thereof. A microparticle according to claim 2, wherein said crosslinking agent is selected from the group consisting of Ca, sodium tripolyphosphate and vanillin. The microparticle according to claim 1, in which the weight ratio of chitosan to casein is 1: 5 ÷ 100, preferably about 1: 14 ÷ 40.6. A microparticle according to claim 1, wherein the probiotic bacterium is selected from the group comprising bacteria of the genus Bifidobacterium and bacteria of the genus Lactobacillus. A microparticle according to claim 1, wherein the probiotic bacterium is selected from the group consisting of bacteria Lactobacillus plantarum and bacteria Lactobacillus casei. The microparticle according to any one of paragraphs. 1-7, in which its size is in the range from 1 to 40 microns, preferably from 2 to 12 microns. The method of producing microparticles according to paragraphs. 1-8, including mixing casein or a source of casein, probiotic bacteria and chitosan. 10. The method of claim 9, wherein the aqueous casein solution or casein source, the suspension of probiotic bacteria and the chitosan aqueous solution are mixed. The method of claim 9, wherein said casein source is sodium caseinate. The method of claim 9, further comprising adding a crosslinking agent. The method of claim 12, wherein said crosslinking agent is added as an aqueous solution. The method of claim 9, which comprises treating a mixture of casein or a casein source, probiotic bacteria, chitosan and, optionally, a crosslinking agent, at least1. Микро
