Platforms comprising at least one lymphocyte affecting molecule and at leastone molecular complex that, when bound to an antigen, engages a uniqueclonotype lymphocyte receptor can be used to induce and expand therapeuticallyuseful numbers of specific lymphocyte populations. Antigen presentingplatforms comprising a T cell affecting molecule and an antigen presentingcomplex can induce and expand antigen-specific T cells in the presence ofrelevant peptides, providing reproducible and economical methods forgenerating therapeutic numbers of such cells. Antibody inducing platformscomprising a B cell affecting molecule and a molecular complex that engagesMHC-antigen complexes on a B cell surface can be used to induce and expand Bcells that produce antibodies with particular specificities.
