PROBLEM TO BE SOLVED: To provide methods for establishing chimerism, reducing the severity or duration of graft versus host disease, treating or ameliorating symptoms of sarcopenia, metabolic disorders and hematologic disorders, such as hematologic malignancies, and treating or ameliorating symptoms of ischemic encephalopathy (e.g., hypoxic ischemic encephalopathy) and other central nervous system injuries.SOLUTION: A method comprises administering, to a subject to be treated, a composition comprising an isolated human placental perfusate, where the human placental perfusate comprises at least 6×105 CD34+ cells.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2020,JPO&INPIT【課題】キメリズムを確立し、移植片対宿主病の重症度又は持続期間を減少させ、サルコペニア、代謝障害、及び血液学的悪性腫瘍などの血液学的障害の症状を治療又は寛解し、虚血性脳症（例えば、低酸素性虚血性脳症）及び他の中枢神経系損傷の症状を治療又は寛解するための方法の提供。【解決手段】単離されたヒト胎盤灌流液を含む組成物であって、該ヒト胎盤灌流液が、少なくとも６×１０５個のＣＤ３４＋細胞を含む前記組成物を、治療対象に投与することを含む方法。【選択図】図１
