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As the antagonist of Basque V1a receptor
专利权人:
RICHTER GEDEON NYRT.
发明人:
VUKICS, KRISZTINA,DR. SZONDIN KORDS, KRISZTINA,DR. BATA, IMRE,DR. BOZ, VA,DR. BASKA, FERENC
申请号:
ARP180103643
公开号:
AR113933A1
申请日:
2018.12.13
申请国别(地区):
AR
年份:
2020
代理人:
摘要:
1. This substance refers to 5,6-dihydro-4h - [1,2,4] triazole [4] derivative; 3-a. [1] benzazepina (1) and / or its salts and / or geometric isomers and / or their stereoisomers and / or their corresponding isomers and / or their isomers and / or their racemates and / or their bioactive metabolites and / or their adults and / or their solutions and / or their hydrates and / or polymers, As a modulator of V1a receiver, it mainly acts against (or) the periphery, especially against the V1a receiver.It also refers to pharmaceutical components containing these compounds, or used in conjunction with one or more other effective principles, and in the treatment and / or prevention of diseases or diseases related to the function of V1a receptors. 1: The general equation compound (1) is characterized by that ring a is a cyclopropyl group or a non cyclopropyl group; and-C(o)……-Ch832222-,-Well-C8321833183318324; - asphalt-n (R1 831222) - or connect if ring B is in; o-n (c8321833838324); asphalt) 832222;C (o) oc8321833183318324;; asphalt, c8321833183838324;; alternative halogen substituted asphalt, c832183318331838324;; halogen or halogen if ring B is not present; ring B is an alternative heteromorphic, arilo or heterocyclic compound; or - Y-A collectively represents a 3H helix [2-benzofuran-1, 4 '- piperidin-ilo]; or (2) group;O formula group (3);O formula group (4);R1 is a hydrogen, halogen, c832131;Or8310o halogen; o R2 and R3 together represent an O - (ch832222) 8344;]The results show that: oxo o = N-OH; r8308y and r83099 are independent hydrogen; c83218331838324; Oh, halogen, cyclopentanylchia, arilo or nr831223 substituted asphalt; r831393; r831393;Cy1;c(o)R8311;-S (o832224) r830407 or c832283318324; asphalt; or r83088 and r8309 form a different cycle with N; r8310 is a hydrogen; c8332183318324; alternative asphalt is replaced by OH group, halogen group and cy2o group; r8310 is hydrogen; c8332183318324; alternative asphalt is replaced by OH group, halogen group and cy2o gr
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